The Effect of Remifentanil– Propofol Compared with Fentanyl– Propofol on Urine Output in Patients Undergoing Lumbar Posterior Spinal Fusion

Abstract

Background: Remifentanil is a narcotic drug used in anaesthesia for establishment of hemodynamic stability. The purpose of this study was to compare the effects of remifentanil and fentanyl on urine excretion. Methods: In a randomized clinical trial, 60 patients, who were candidates for elective surgery for lumbar posterior spinal fusion, were divided randomly into two groups of 30 as remifentanil – propofol (R) and fentanyl- propofol (F). Maintenance of anaesthesia drugs in group R included 100 mcg/kg/min propofol and 0.5- 0.25 mcg/kg/min remifentanil. It included 100 mcg/kg/min propofol and 5- 0.5 mcg/kg/min fentanyl in group F. Vital signs and urine output were recorded every half an hour. Results: The mean age of patients was 49.5± 12.7 years. Urine output in group R showed significantly greater reduction than in group F (p< 0.001). Increase of urine output was seen in both groups over the time. Conclusion: Urine output in patients undergoing lumbar posterior spinal fusion who received remifentanil was less compared to the fentanyl group.

Keywords

• remifentanil
• propofol
• fentanyl
• urine output
• lumbar posterior spinal fusion