Effects of Bengkoang (Pachyrhizus erosus (L) Urb Juice in Hampering Blood Glucose in Rat Models

Abstract

Background : The prevalence of diabetes mellitus in Indonesia tends to increase and is predicted to reach 21.3 millions in 2030. Bengkoang (Pachyrhizus erosus (L) Urb. is one of the traditional medicine frequently used in diabetes treatment.The objective of this study is to assess the effectiveness of bengkoang juice in hampering blood glucose increase. Methods : Fourty alloxan-induced diabetic Wistar rats were used in this study. After 16 hours of fasting, the blood glucose was measured using glucometer EasyTouch Blood Glucose/Cholesterol/Uric Acid Multi-Function Monitoring System. The positive control group was given 7 ml of distilled water and 50% glucose solution with 2.5 g/kg dosage while the study group were given 7 ml of bengkoang juice and 50% glucose solution with 2.5 g/kg dosage. Blood glucose was re-checked after 2 hours. This procedure was performed in October 2012.The results were analyzed using Student’s T-test with α = 0.05. Results: The result shows a significant difference in blood glucose increase between the control and study groups with a score of 121.11 mg/dL and 324.45 mg/dL respectively. This result shows that bengkoang juice increases blood glucose level in Wistar rats. Conclusions: In conclusion, bengkoang (Pachyrhizus erosus (L) Urb. juice has no effect in hampering the blood glucose level increase in Wistar rats. [AMJ.2014;1(1):25–9]

Keywords

• Alloxan
• blood glucose
• diabetes mellitus
• Pachyrhizus erosus (L) Urb.