Molecules
(Sep 2022)
A Supramolecular Approach to Antimicrobial Surfaces
Valentina Gazzola,
Pietro Grisoli,
Valeria Amendola,
Giacomo Dacarro,
Carlo Mangano,
Piersandro Pallavicini,
Antonio Poggi,
Silvia Rossi,
Barbara Vigani,
Angelo Taglietti
Affiliations
Valentina Gazzola
Department of Chemistry, University of Pavia, Viale Torquato Taramelli 12, 27100 Pavia, Italy
Pietro Grisoli
Department of Drug Sciences, University of Pavia, Viale Torquato Taramelli 12, 27100 Pavia, Italy
Valeria Amendola
Department of Chemistry, University of Pavia, Viale Torquato Taramelli 12, 27100 Pavia, Italy
Giacomo Dacarro
Department of Chemistry, University of Pavia, Viale Torquato Taramelli 12, 27100 Pavia, Italy
Carlo Mangano
Department of Chemistry, University of Pavia, Viale Torquato Taramelli 12, 27100 Pavia, Italy
Piersandro Pallavicini
Department of Chemistry, University of Pavia, Viale Torquato Taramelli 12, 27100 Pavia, Italy
Antonio Poggi
Department of Chemistry, University of Pavia, Viale Torquato Taramelli 12, 27100 Pavia, Italy
Silvia Rossi
Department of Drug Sciences, University of Pavia, Viale Torquato Taramelli 12, 27100 Pavia, Italy
Barbara Vigani
Department of Drug Sciences, University of Pavia, Viale Torquato Taramelli 12, 27100 Pavia, Italy
Angelo Taglietti
Department of Chemistry, University of Pavia, Viale Torquato Taramelli 12, 27100 Pavia, Italy
DOI
https://doi.org/10.3390/molecules27175731
Journal volume & issue
Vol. 27,
no. 17
p.
5731
Abstract
Read online
In this paper, we report on the preparation of Imidazole-functionalized glass surfaces, demonstrating the ability of a dinuclear Cu(II) complex of a macrocyclic ligand to give a “cascade” interaction with the deprotonated forms of grafted imidazole moieties. In this way, we realized a prototypal example of an antimicrobial surface based on a supramolecular approach, obtaining a neat microbicidal effect using low amounts of the described copper complex.
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