Treatment Opportunities for Colorectal Liver Metastases

Abstract

Colorectal liver metastases (CLM) are the most common hepatic malignancy and are caused by disseminated tumour cells (DTCs) seeded early in the tumourigenesis of colorectal cancer. Despite optimal treatment, CLM are associated with high mortality rates. This review provides an overview of three promising strategies to extend survival in CLM: treatment of DTCs, immunotherapy, and new surgical resection techniques.

Keywords

• colorectal liver metastases (clm)
• circulating tumour cells
• immunotherapy
• associating liver partition and portal vein ligation for staged hepatectomy (alpps)
• resection and partial liver segment ii/iii transplantation with delayed total hepatectomy (rapid)