GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21

Nature Communications. 2018;9(1):1-8 DOI 10.1038/s41467-017-02596-9

 

Journal Homepage

Journal Title: Nature Communications

ISSN: 2041-1723 (Online)

Publisher: Nature Publishing Group

LCC Subject Category: Science

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS


Joseph L. Wiemels (Department of Epidemiology and Biostatistics, University of California San Francisco)

Kyle M. Walsh (Department of Epidemiology and Biostatistics, University of California San Francisco)

Adam J. de Smith (Department of Epidemiology and Biostatistics, University of California San Francisco)

Catherine Metayer (School of Public Health, University of California Berkeley)

Semira Gonseth (Department of Epidemiology and Biostatistics, University of California San Francisco)

Helen M. Hansen (Department of Neurological Surgery, University of California San Francisco)

Stephen S. Francis (Department of Epidemiology and Biostatistics, University of California San Francisco)

Juhi Ojha (Department of Epidemiology and Biostatistics, University of California San Francisco)

Ivan Smirnov (Department of Neurological Surgery, University of California San Francisco)

Lisa Barcellos (School of Public Health, University of California Berkeley)

Xiaorong Xiao (School of Public Health, University of California Berkeley)

Libby Morimoto (School of Public Health, University of California Berkeley)

Roberta McKean-Cowdin (Department of Preventative Medicine, University of Southern California)

Rong Wang (Department of Chronic Diseases Epidemiology, School of Public Health, Yale University)

Herbert Yu (University of Hawaii Cancer Center)

Josephine Hoh (Department of Chronic Diseases Epidemiology, School of Public Health, Yale University)

Andrew T. DeWan (Department of Chronic Diseases Epidemiology, School of Public Health, Yale University)

Xiaomei Ma (Department of Chronic Diseases Epidemiology, School of Public Health, Yale University)

EDITORIAL INFORMATION

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Instructions for authors

Time From Submission to Publication: 28 weeks

 

Abstract | Full Text

Childhood acute lymphoblastic leukemia is common in Latino Americans. Here, the authors conduct a genome-wide association study in a Californian cohort containing children of Latino heritage, and identify loci on 17q12 and 8q24 which may affect hematopoietic and growth-regulation pathways.