Distribution of genotypes and alleles of the aldosterone-synthase gene in patients with abdominal obesity

Abstract

We observed 140 patients with abdominal obesity (AO) (IDF, 2005), the residents of St. Petersburg (44.6 ± 0.6 years). Metabolic syndrome (MS) (IDF, 2005) was diagnosed in 49.2% of patients with AO. The most frequent component of MS in patients with AO was arterial hypertension (AH). The distribution of genotypes and -alleles of the aldosterone-synthase gene in patients with AO and in the comparison group (56 subjects without AO, 41.0 ± 1.1 years) didn't differ (p> 0.05). Levels of both systolic and diastolic blood pressure (BP) were higher in carriers of -344T allele of aldosterone-synthase gene. Plasma renin activity, plasma aldosterone and glucose levels, anthropometric parameters, serum blood lipids and carbohydrate metabolism indices in obese patients with different genotypes of aldosterone-synthase gene didn't differ. -344T allele of aldosterone-synthase gene in patients with AO is associated with the increased risk of AH.

Keywords

• абдоминальное ожирение
• артериальная гипертензия
• ренин-ангиотензин-альдостероновая система
• полиморфизм
• альдостерон-синтаза
• abdominal obesity
• arterial hypertension
• renin-angiotensin-aldosterone system
• polymorphism
• aldosterone-synthase