Basic & Clinical Cancer Research (Jan 2023)

A New Method for 18FDG generating using Geant4/ Gate7

  • Abuzar Shakeri,
  • Ebrahim Heidari,
  • Seyedeh Nasrin Hosseini Motlagh,
  • Hamid Reza Vanaei

Journal volume & issue
Vol. 13, no. 4

Abstract

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Fluorine 18-deoxyglucose is often used in Positron Emission Tomography devices. Positron Emission Tomography imaging is one of the useful tools which is used for cancer detection and its management. Positron Emission Tomography growth is limited due to problems that depend on the production of Fluorine-18. Imaging results are strongly depending on the information of nuclear reaction cross-section data. This study is presented to calculate different quantities such as stopping power, CSDA range, and simulated and distributed absorbed dose of Fluorine-18 in water. In order to access these goals, we use Geant4/Gate7 simulation and the theoretical Bethe-Bloch model. The results of this simulation and the theoretical model presented are in good agreement with each other. The important point of this paper is the presentation of a theoretical approach in order to the production of Fluorine-18 using protons generated through the main D(d;p) Tand side 3He(d;p)4He nuclear fusion reaction in which uses Helium-3 is catalyzed.

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