Renal Impairment Impact and Survival Analysis in a Romanian Cohort of HIV-1(F1)-Infected Children and Adolescents
Raluca Isac,
Rodica Costa,
Mirela Frandes,
Voichita Elena Lazureanu,
Ramona Florina Stroescu,
Ruxandra Maria Steflea,
Iulia-Cristina Bagiu,
Florin George Horhat,
Gratiana Nicoleta Chicin,
Avram Cecilia Roberta,
Pacurari Alina Cornelia,
Gabriela Doros,
Mihai Gafencu
Affiliations
Raluca Isac
Pediatric Department, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania
Rodica Costa
Emergency Hospital for Children “Louis Turcanu”, Iosif Nemoianu Street, No. 2, 300011 Timișoara, Romania
Mirela Frandes
Department of Functional Sciences, Discipline of Biostatistics and Medical Informatics, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania
Voichita Elena Lazureanu
Department of Infectious Diseases, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania
Ramona Florina Stroescu
Pediatric Department, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania
Ruxandra Maria Steflea
Pediatric Department, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania
Iulia-Cristina Bagiu
Department of Microbiology, Multidisciplinary Research Center on Antimicrobial Resistance, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania
Florin George Horhat
Department of Microbiology, Multidisciplinary Research Center on Antimicrobial Resistance, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania
Gratiana Nicoleta Chicin
Department of Epidemiology, Infectious Diseases, Preventive Medicine and Epidemiology, “VASILE GOLDIŞ” Western University of Arad, Revolutiei Boulevard, No. 94–96, 310025 Arad, Romania
Avram Cecilia Roberta
Department of Physiology and Pathophysiology, Medicine Faculty, “VASILE GOLDIŞ” Western University of Arad, Revolutiei Boulevard, No. 94–96, 310025 Arad, Romania
Pacurari Alina Cornelia
MedLife HyperClinic, Eroilor de la Tisa Boulevard, No. 28, 300551 Timișoara, Romania
Gabriela Doros
Pediatric Department, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania
Mihai Gafencu
Pediatric Department, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania
Human immunodeficiency virus (HIV) is a lentivirus that is transmissible through blood and other body fluids. During the late 1980s and early 1990s, an estimated 10,000 Romanian children were infected with HIV-1 subtype F nosocomially through contaminated needles and untested blood transfusions. Romania was a special case in the global acquired immunodeficiency syndrome (AIDS) pandemic, displaying the largest population of HIV-infected children by parental transmission between 1987–1990. In total, 205 HIV-infected patients from the western part of Romania were analyzed in this retrospective study. Over 70% of them had experienced horizontal transmission from an unknown source, while vertical transmission was identified in only five cases. Most patients had a moderate to severe clinical manifestation of HIV infection, 77.56% had undergone antiretroviral (ARV) treatment, most of them (71.21%) had experienced no adverse reactions and many of those with HIV (90.73%) had an undetectable viral load. Renal impairment was detected in one third of patients (34.63%). Patients born before 1990, male patients, patients diagnosed with HIV before the age of 10, and those undernourished or with renal impairment had a shorter average survival time than the group born after 1990, female patients, patients receiving ARV treatment, patients with a normal body mass index (BMI) and those without renal impairment. Periodical monitoring of the estimated glomerular filtration rate (eGFR) level, as well as the detection of protein excretion, should be taken into consideration worldwide when monitoring HIV-positive patients; this in order to detect even asymptomatic chronic kidney disease (CKD), and to manage these patients and prolong their lives.
