Recent Developments in Parathyroid Hormone Type 1 Receptor and Kidney Disease

Abstract

Parathyroid hormone type 1 receptor (PTH1R), a member of the G-protein-coupled receptor family, is extensively expressed in the human body and is involved in various processes such as embryonic development, calcium and phosphorus homeostasis, body metabolism and tumorigenesis. PTH1R is highly expressed in the kidney, and its activation is involved in the development and progression of renal diseases though multiple mechanisms and complicated pathways, and is closely associated with a variety of renal diseases such as diabetic nephropathy, glomerulonephritis, acute kidney injury, and chronic kidney disease. This article reviews recent studies about the function of PTH1R, and its role and mechanism of action in renal diseases, and provides an in-depth discussion on the relationship and related mechanisms between PTH1R and kidney diseases, offering new ideas for the diagnosis and treatment of kidney diseases.

Keywords

• kidney diseases|receptor, parathyroid hormone, type 1|parathyroid hormone-related protein|parathyroid hormone|diabetic nephropathies|glomerulonephritis|chronic kidney disease|acute kidney injury|review