Nature Communications (May 2022)
Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction
- Weijia Sun,
- Shuai Guo,
- Yuheng Li,
- JianWei Li,
- Caizhi Liu,
- Yafei Chen,
- Xuzhao Wang,
- Yingjun Tan,
- Hua Tian,
- Cheng Wang,
- Ruikai Du,
- Guohui Zhong,
- Sai Shi,
- Biao Ma,
- Chang Qu,
- Jingxuan Fu,
- Xiaoyan Jin,
- Dingsheng Zhao,
- Yong Zhan,
- Shukuan Ling,
- Hailong An,
- Yingxian Li
Affiliations
- Weijia Sun
- State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
- Shuai Guo
- Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology
- Yuheng Li
- State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
- JianWei Li
- State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
- Caizhi Liu
- State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
- Yafei Chen
- Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology
- Xuzhao Wang
- Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology
- Yingjun Tan
- State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
- Hua Tian
- Department of Orthopedics /Engineering Research Center of Bone and Joint Precision Medicine /Beijing Key Laboratory of Spinal Disease Research, Peking University the Third Hospital
- Cheng Wang
- Department of Orthopedics /Engineering Research Center of Bone and Joint Precision Medicine /Beijing Key Laboratory of Spinal Disease Research, Peking University the Third Hospital
- Ruikai Du
- State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
- Guohui Zhong
- State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
- Sai Shi
- Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology
- Biao Ma
- Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology
- Chang Qu
- Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology
- Jingxuan Fu
- Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology
- Xiaoyan Jin
- State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
- Dingsheng Zhao
- State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
- Yong Zhan
- Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology
- Shukuan Ling
- State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
- Hailong An
- Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology
- Yingxian Li
- State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
- DOI
- https://doi.org/10.1038/s41467-022-30625-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Osteoclast over-activation leads to bone loss and chloride homeostasis is important for osteoclast function. Here, the authors show that Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction.
