Nature Communications (Nov 2022)
Site-selective photocatalytic functionalization of peptides and proteins at selenocysteine
- Luke J. Dowman,
- Sameer S. Kulkarni,
- Juan V. Alegre-Requena,
- Andrew M. Giltrap,
- Alexander R. Norman,
- Ashish Sharma,
- Liliana C. Gallegos,
- Angus S. Mackay,
- Adarshi P. Welegedara,
- Emma E. Watson,
- Damian van Raad,
- Gerhard Niederacher,
- Susanne Huhmann,
- Nicholas Proschogo,
- Karishma Patel,
- Mark Larance,
- Christian F. W. Becker,
- Joel P. Mackay,
- Girish Lakhwani,
- Thomas Huber,
- Robert S. Paton,
- Richard J. Payne
Affiliations
- Luke J. Dowman
- School of Chemistry, The University of Sydney
- Sameer S. Kulkarni
- School of Chemistry, The University of Sydney
- Juan V. Alegre-Requena
- Department of Chemistry, Colorado State University
- Andrew M. Giltrap
- School of Chemistry, The University of Sydney
- Alexander R. Norman
- School of Chemistry, The University of Sydney
- Ashish Sharma
- School of Chemistry, The University of Sydney
- Liliana C. Gallegos
- Department of Chemistry, Colorado State University
- Angus S. Mackay
- School of Chemistry, The University of Sydney
- Adarshi P. Welegedara
- Research School of Chemistry, Australian National University
- Emma E. Watson
- School of Chemistry, The University of Sydney
- Damian van Raad
- Research School of Chemistry, Australian National University
- Gerhard Niederacher
- Institute of Biological Chemistry, Faculty of Chemistry, University of Vienna
- Susanne Huhmann
- Institute of Biological Chemistry, Faculty of Chemistry, University of Vienna
- Nicholas Proschogo
- School of Chemistry, The University of Sydney
- Karishma Patel
- School of Life and Environmental Sciences, The University of Sydney
- Mark Larance
- Charles Perkins Centre and School of Medical Sciences, The University of Sydney
- Christian F. W. Becker
- Institute of Biological Chemistry, Faculty of Chemistry, University of Vienna
- Joel P. Mackay
- School of Life and Environmental Sciences, The University of Sydney
- Girish Lakhwani
- School of Chemistry, The University of Sydney
- Thomas Huber
- Research School of Chemistry, Australian National University
- Robert S. Paton
- Department of Chemistry, Colorado State University
- Richard J. Payne
- School of Chemistry, The University of Sydney
- DOI
- https://doi.org/10.1038/s41467-022-34530-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
The modification of peptides and proteins for application in drug discovery and chemical biology is currently a rapidly growing field of research. Here, the authors report a photocatalytic diselenide contraction method for the dimerization and site-specific functionalisation of peptides and protein.
