Derivation of induced pluripotent stem cell SJTUi003-A from a 69-year-old Chinese Han Sporadic Alzheimer’s disease patient with APOEε3/ε4 genetic background

Hui Li; Bei Zhang; Zhiqiang Shi; Hui Wu; Shuya Mei; Tianyi Ai; An Shi; Lihui Wang; Mingli Zhu; Jiajia Tang

Stem Cell Research (Sep 2023)

Derivation of induced pluripotent stem cell SJTUi003-A from a 69-year-old Chinese Han Sporadic Alzheimer’s disease patient with APOEε3/ε4 genetic background

Hui Li,
Bei Zhang,
Zhiqiang Shi,
Hui Wu,
Shuya Mei,
Tianyi Ai,
An Shi,
Lihui Wang,
Mingli Zhu,
Jiajia Tang

Affiliations

Hui Li: Department of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No.1630 Dongfang Road, Shanghai 200127, China
Bei Zhang: Department of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, China
Zhiqiang Shi: Department of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No.1630 Dongfang Road, Shanghai 200127, China
Hui Wu: Department of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No.1630 Dongfang Road, Shanghai 200127, China
Shuya Mei: Department of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No.1630 Dongfang Road, Shanghai 200127, China
Tianyi Ai: Department of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No.1630 Dongfang Road, Shanghai 200127, China
An Shi: Department of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No.1630 Dongfang Road, Shanghai 200127, China
Lihui Wang: Department of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No.1630 Dongfang Road, Shanghai 200127, China
Mingli Zhu: Department of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No.1630 Dongfang Road, Shanghai 200127, China; Corresponding authors.
Jiajia Tang: Department of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No.1630 Dongfang Road, Shanghai 200127, China; Corresponding authors.

Journal volume & issue: Vol. 71
p. 103142

Abstract

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Alzheimer’s disease (AD) is an age-related and progressive neurodegenerative disease. In this study, we generated an induced pluripotent stem cell (iPSC) line from the dermal fibroblasts of a 69-year-old female patient carrying APOEε3/ε4 allele and diagnosed with sporadic AD. The iPSC line will be a useful tool for investigating the pathogenesis mechanisms and for drug tests in AD.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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