Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex

Abstract

Aryl hydrocarbon receptor (AHR) is a sensor of the chemical environment including pollutants, diet components and metabolites. Here, authors determine the structure of the indirubin-bound AHR cytosolic complex providing mechanistic insights into ligand-binding promiscuity and selectivity.