Increased red cell distribution width level is associated with absence of coronary collateral vessels in patients with acute coronary syndromes

Abstract

Objectives: Several studies have evaluated a relationship between increased red cell distribution width (RDW) and morbidity and mortality of acute coronary syndrome (ACS). In this study, we aimed to investigate the association of serum RDW levels and development of coronary collateral vessel (CCV) in patients with ACS. Study design: We evaluated 226 patients with ACS in this prospective and cross-sectional study. Traditional laboratory and clinical parameters and serum RDW levels were measured on admission. All patients underwent coronary angiography on the first day after admission and patients with >80% stenosis were included in the study. The CCV was graded according to the Rentrop scoring system, and a Rentrop grade 0 was accepted as no CCV development (Group 1), while Rentrop grades 1-2-3 were accepted as presence of CCV development (Group 2). Results: Only levels of RDW were significantly higher in Group 1 than in Group 2 (Group 1 RDW 14.6+-1.9, Group 2 RDW 14.1+-1.4, p=0.02). The predictive value of serum RDW level for absence of collaterals (sensitivity of 58% and specificity of 54%, area under the receiver operating characteristic (ROC) curve = 0.573) was 13.90. Conclusion: We found that high levels of RDW were associated with absence of CCV in patients with ACS.

Keywords

• acute coronary syndrome
• biological markers
• coronary circulation
• erythrocyte indices; red cell distribution width.