Communications Biology (Jun 2022)
Distinct dissociation rates of murine and human norovirus P-domain dimers suggest a role of dimer stability in virus-host interactions
- Robert Creutznacher,
- Thorben Maass,
- Jasmin Dülfer,
- Clara Feldmann,
- Veronika Hartmann,
- Miranda Sophie Lane,
- Jan Knickmann,
- Leon Torben Westermann,
- Lars Thiede,
- Thomas J. Smith,
- Charlotte Uetrecht,
- Alvaro Mallagaray,
- Christopher A. Waudby,
- Stefan Taube,
- Thomas Peters
Affiliations
- Robert Creutznacher
- University of Lübeck, Center of Structural and Cell Biology in Medicine (CSCM), Institute of Chemistry and Metabolomics
- Thorben Maass
- University of Lübeck, Center of Structural and Cell Biology in Medicine (CSCM), Institute of Chemistry and Metabolomics
- Jasmin Dülfer
- Leibniz Institute of Virology (LIV)
- Clara Feldmann
- University of Lübeck, Center of Structural and Cell Biology in Medicine (CSCM), Institute of Chemistry and Metabolomics
- Veronika Hartmann
- University of Lübeck, Center of Structural and Cell Biology in Medicine (CSCM), Institute of Virology and Cell Biology
- Miranda Sophie Lane
- University of Lübeck, Center of Structural and Cell Biology in Medicine (CSCM), Institute of Virology and Cell Biology
- Jan Knickmann
- University of Lübeck, Center of Structural and Cell Biology in Medicine (CSCM), Institute of Virology and Cell Biology
- Leon Torben Westermann
- University of Lübeck, Center of Structural and Cell Biology in Medicine (CSCM), Institute of Chemistry and Metabolomics
- Lars Thiede
- Leibniz Institute of Virology (LIV)
- Thomas J. Smith
- University of Texas Medical Branch at Galveston, Department of Biochemistry and Molecular Biology, 301 University Boulevard
- Charlotte Uetrecht
- Leibniz Institute of Virology (LIV)
- Alvaro Mallagaray
- University of Lübeck, Center of Structural and Cell Biology in Medicine (CSCM), Institute of Chemistry and Metabolomics
- Christopher A. Waudby
- Institute of Structural and Molecular Biology, University College London
- Stefan Taube
- University of Lübeck, Center of Structural and Cell Biology in Medicine (CSCM), Institute of Virology and Cell Biology
- Thomas Peters
- University of Lübeck, Center of Structural and Cell Biology in Medicine (CSCM), Institute of Chemistry and Metabolomics
- DOI
- https://doi.org/10.1038/s42003-022-03497-4
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 13
Abstract
NMR and native mass spectrometry reveal that the major capsid VP1 protein from murine and human norovirus exhibit distinct behaviors and are differentially regulated by the binding of glycochenodeoxycholic acid.
