CARDIOMETABOLIC RISK PREDICTION IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE COMBINED WITH SUBCLINICAL HYPOTHYROIDISM

Abstract

One of the most common diseases of our time is non-alcoholic fatty liver disease (NAFLD). Recently published research results indicate that patients with NAFLD along with traditional risk factors for cardiovascular diseases (CVD) have "new" risk factors such as endothelial dysfunction (ED), carotid intima-media thickness (CIMT), an increase in the CRP level, as well as risk factors combined into the Framingham scale. It is also known that combination of NAFLD with subclinical hypothyroidism (SH) forms an abnormal metabolic phenotype, which is associated with cardiometabolic risk factors. The study of cardiometabolic predictors and vascular markers in patients with NAFLD in combination with SH will provide an opportunity to improve the strategy of cardiovascular events prevention in such comorbid patients.

Keywords

• cardiometabolic risk
• non-alcoholic fatty liver disease
• subclinical hypothyroidism
• prediction
• binary regression logistic analysis
• validation of prognostic models