Green synthesis of zinc oxide nanoparticles using leaf extracts of Raphanus sativus var. Longipinnatus and evaluation of their anticancer property in A549 cell lines

Abstract

In 21 st century, nanomedicine has turned out to be an emergent modulus operation for the diagnosis and treatment for cancer. The current study includes the Green synthesis of zinc oxide nanoparticles (ZnO NPs) from the leaves of Raphanus sativus var. Longipinnatus and interpretation of its anticancer activity. Synthesized ZnO NPs were investigated by UV–vis, FTIR, particle size analysis, SEM, XRD and its anticancer activity using A549 cell lines. The UV–vis and particle size confirmed the developed ZnO NPs are in nanoscale. The FTIR studies confirmed the presence of various functional groups. SEM and XRD pictures confirmed the partial crystal spherical shape and wurtzite crystal nature. The cytotoxicity results pointed out the enhanced cytotoxic effect of the synthesized ZnO NPs. This is the first attempt of Raphanus sativus var. Longipinnatus facilitated synthesis of ZnO NPs as anticancer agents and may subsequently be potential chemopreventive agent against other cancer treatment in future.

Keywords

• Raphanus sativus var. Longipinnatus.
• Green synthesis
• Phytoconstituents
• Zinc oxide nanoparticles
• In vitro cytotoxicity
• Lung cancer