Is Evolutionary Conservation a Useful Predictor for Cancer Long Noncoding RNAs? Insights from the Cancer LncRNA Census 3

Adrienne Vancura; Alejandro H. Gutierrez; Thorben Hennig; Carlos Pulido-Quetglas; Frank J. Slack; Rory Johnson; Simon Haefliger

doi:10.3390/ncrna8060082

Non-Coding RNA (Dec 2022)

Is Evolutionary Conservation a Useful Predictor for Cancer Long Noncoding RNAs? Insights from the Cancer LncRNA Census 3

Adrienne Vancura,
Alejandro H. Gutierrez,
Thorben Hennig,
Carlos Pulido-Quetglas,
Frank J. Slack,
Rory Johnson,
Simon Haefliger

Affiliations

Adrienne Vancura: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
Alejandro H. Gutierrez: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
Thorben Hennig: HMS Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center Cancer Center, Harvard Medical School, Boston, MA 02215, USA
Carlos Pulido-Quetglas: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
Frank J. Slack: HMS Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center Cancer Center, Harvard Medical School, Boston, MA 02215, USA
Rory Johnson: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
Simon Haefliger: Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland

DOI: https://doi.org/10.3390/ncrna8060082
Journal volume & issue: Vol. 8, no. 6
p. 82

Abstract

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Evolutionary conservation is a measure of gene functionality that is widely used to prioritise long noncoding RNAs (lncRNA) in cancer research. Intriguingly, while updating our Cancer LncRNA Census (CLC), we observed an inverse relationship between year of discovery and evolutionary conservation. This observation is specific to cancer over other diseases, implying a sampling bias in the selection of lncRNA candidates and casting doubt on the value of evolutionary metrics for the prioritisation of cancer-related lncRNAs.

Published in Non-Coding RNA

ISSN: 2311-553X (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Genetics
Website: https://www.mdpi.com/journal/ncrna

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Abstract

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