World Journal of Surgical Oncology (Jul 2018)

Differences in gene mutations according to gender among patients with colorectal cancer

  • Yi-Jian Tsai,
  • Sheng-Chieh Huang,
  • Hung-Hsin Lin,
  • Chun-Chi Lin,
  • Yuan-Tzu Lan,
  • Huann-Sheng Wang,
  • Shung-Haur Yang,
  • Jeng-Kai Jiang,
  • Wei-Shone Chen,
  • Tzu-chen Lin,
  • Jen-Kou Lin,
  • Shih-Ching Chang

DOI
https://doi.org/10.1186/s12957-018-1431-5
Journal volume & issue
Vol. 16, no. 1
pp. 1 – 5

Abstract

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Abstract Background The incidence, site distribution, and mortality rates of patients with colorectal cancer differ according to gender. We investigated gene mutations in colorectal patients and wanted to examine gender-specific differences. Methods A total of 1505 patients who underwent surgical intervention for colorectal cancer were recruited from March 2000 to January 2010 at Taipei Veterans’ General Hospital and investigated for gene mutations in K-ras, N-ras, H-ras, BRAF, loss of 18q, APC, p53, SMAD4, TGF-β, PIK3CA, PTEN, FBXW7, AKT1, and MSI. Results There were significant differences between male and female patients in terms of tumor location (p < 0.0001) and pathological stage (p = 0.011). The female patients had significantly more gene mutations in BRAF (6.4 vs. 3.3%, OR 1.985, p = 0.006), TGF-β (4.7 vs. 2.5%, OR 1.887, p = 0.027), and revealed a MSI-high status (14.0 vs. 8.3%, OR 1.800, p = 0.001) than male patients. Male patients had significantly more gene mutations in N-ras (5.1 vs. 2.3%, OR 2.227, p = 0.012); however, the significance was maintained only for mutations in BRAF (OR 2.104, p = 0.038), MSI-high status (OR 2.003 p = 0.001), and N-ras (OR 3.000, p = 0.010) after the groups were divided by tumor site. Conclusion Gene mutations in BRAF, MSI-high status, and N-ras differ according to gender among patients with colorectal cancer.

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