Nature Communications (Dec 2020)

Structure of human RNA polymerase III

  • Ewan Phillip Ramsay,
  • Guillermo Abascal-Palacios,
  • Julia L. Daiß,
  • Helen King,
  • Jerome Gouge,
  • Michael Pilsl,
  • Fabienne Beuron,
  • Edward Morris,
  • Philip Gunkel,
  • Christoph Engel,
  • Alessandro Vannini

DOI
https://doi.org/10.1038/s41467-020-20262-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

Read online

The eukaryotic RNA Polymerase III transcribes tRNAs, some ribosomal and spliceosomal RNAs. Here, the authors resolve a cryo-EM structure of human RNA Polymerase III in its apo form and complemented it with crystal structures and SAXS analysis of RPC5, revealing insights into the molecular mechanisms of Pol III transcription.