Breast Cancer Detection via Global and Local Features using Digital Histology Images

Abstract

Globally, breast cancer (BC) is the prevailing cause of unusual deaths in women. Breast tumor (BT) is a primary symptom and may lead to BC. Digital histology (DH) image modality is a gold standard medical test for a definite diagnosis of BC. Traditionally, DH images are visually examined by two or more pathologists to come up with a consensus for authentic BC detection which may cause a high error rate. Therefore, researchers had developed automated BC detection models using a machine learning (ML) based approach. Thus, this study aims to develop a BC detection model through ten feature extraction methods which extract both local and global type features from publicly available breast histology dataset. The extracted features are sorted by their weights, which are computed by the neighborhood component analysis method. A feature selection algorithm is developed to find the minimum number of discriminating features, evaluated through seven heterogeneous traditional ML classifiers. The proposed ML-based BC detection model acquired 90% accuracy for the initial testing set using 51 Harris features. Whereas, for the extended testing set, only three Harris features is shown 93% accuracy. The proposed BC detection model can assist the doctor in giving a second opinion.