Serotoninergic regulation of colonic motor function

Abstract

The review deals with the serotoninergic regulation of colonic motor function. Serotonin (HT), its receptors and transporter, the enzymes of synthesis and degradation, play an important role in the regulation of colonic motor activity. Activation of 5-НТ1, 5-НТ2В, 5-НТ3, and 5-НТ4 receptors leads to increased colonic motor function. The elevation of serotonin levels determines the higher sensitivity of the colonic wall in irritable bowel syndrome. Serotonin plays a pathogenetic role in the development of ulcerative colitis and colostasis.

Keywords

• colon
• motility
• regulation
• serotonin
• receptors
• transporter