Nature Communications (Apr 2018)
Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways
- David M. Howard,
- Mark J. Adams,
- Masoud Shirali,
- Toni-Kim Clarke,
- Riccardo E. Marioni,
- Gail Davies,
- Jonathan R. I. Coleman,
- Clara Alloza,
- Xueyi Shen,
- Miruna C. Barbu,
- Eleanor M. Wigmore,
- Jude Gibson,
- 23andMe Research Team,
- Saskia P. Hagenaars,
- Cathryn M. Lewis,
- Joey Ward,
- Daniel J. Smith,
- Patrick F. Sullivan,
- Chris S. Haley,
- Gerome Breen,
- Ian J. Deary,
- Andrew M. McIntosh
Affiliations
- David M. Howard
- Division of Psychiatry, University of Edinburgh
- Mark J. Adams
- Division of Psychiatry, University of Edinburgh
- Masoud Shirali
- Division of Psychiatry, University of Edinburgh
- Toni-Kim Clarke
- Division of Psychiatry, University of Edinburgh
- Riccardo E. Marioni
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Gail Davies
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Jonathan R. I. Coleman
- Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London
- Clara Alloza
- Division of Psychiatry, University of Edinburgh
- Xueyi Shen
- Division of Psychiatry, University of Edinburgh
- Miruna C. Barbu
- Division of Psychiatry, University of Edinburgh
- Eleanor M. Wigmore
- Division of Psychiatry, University of Edinburgh
- Jude Gibson
- Division of Psychiatry, University of Edinburgh
- 23andMe Research Team
- Saskia P. Hagenaars
- Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London
- Cathryn M. Lewis
- Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London
- Joey Ward
- Institute of Health and Wellbeing, University of Glasgow
- Daniel J. Smith
- Institute of Health and Wellbeing, University of Glasgow
- Patrick F. Sullivan
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Chris S. Haley
- Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Gerome Breen
- Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London
- Ian J. Deary
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Andrew M. McIntosh
- Division of Psychiatry, University of Edinburgh
- DOI
- https://doi.org/10.1038/s41467-018-03819-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 10
Abstract
The UK Biobank provides data for three depression-related phenotypes. Here, Howard et al. perform a genome-association study for broad depression, probable major depressive disorder (MDD) and hospital record-coded MDD in up to 322,580 UK Biobank participants which highlights excitatory synaptic pathways.
