Nature Communications (Jan 2023)

Arabidopsis DXO1 activates RNMT1 to methylate the mRNA guanosine cap

  • Chen Xiao,
  • Kaien Li,
  • Jingmin Hua,
  • Zhao He,
  • Feng Zhang,
  • Qiongfang Li,
  • Hailei Zhang,
  • Lei Yang,
  • Shuying Pan,
  • Zongwei Cai,
  • Zhiling Yu,
  • Kam-Bo Wong,
  • Yiji Xia

DOI
https://doi.org/10.1038/s41467-023-35903-8
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 12

Abstract

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Arabidopsis DXO1 is a member of the eukaryotic DXO family of decapping enzymes for NAD-capped RNAs. Here the authors show that DXO1 is an essential component in canonical m7G capping of mRNA and activates RNMT1 which methylates the guanosine cap to form the m7G cap.