Nature Communications (Jun 2019)
Sialyl Lewisx-P-selectin cascade mediates tumor–mesothelial adhesion in ascitic fluid shear flow
- Shan-Shan Li,
- Carman K. M. Ip,
- Matthew Y. H. Tang,
- Maggie K. S. Tang,
- Yin Tong,
- Jiangwen Zhang,
- Ayon Ahmed Hassan,
- Abby S. C. Mak,
- Susan Yung,
- Tak-Mao Chan,
- Philip P. Ip,
- Cheuk Lun Lee,
- Philip C. N. Chiu,
- Leo Tsz On Lee,
- Hung-Cheng Lai,
- Jin-Zhang Zeng,
- Ho Cheung Shum,
- Alice S. T. Wong
Affiliations
- Shan-Shan Li
- School of Biological Sciences, University of Hong Kong
- Carman K. M. Ip
- School of Biological Sciences, University of Hong Kong
- Matthew Y. H. Tang
- Department of Mechanical Engineering, University of Hong Kong
- Maggie K. S. Tang
- School of Biological Sciences, University of Hong Kong
- Yin Tong
- School of Biological Sciences, University of Hong Kong
- Jiangwen Zhang
- School of Biological Sciences, University of Hong Kong
- Ayon Ahmed Hassan
- School of Biological Sciences, University of Hong Kong
- Abby S. C. Mak
- School of Biological Sciences, University of Hong Kong
- Susan Yung
- Department of Medicine, University of Hong Kong, Queen Mary Hospital
- Tak-Mao Chan
- Department of Medicine, University of Hong Kong, Queen Mary Hospital
- Philip P. Ip
- Department of Pathology, University of Hong Kong, Queen Mary Hospital
- Cheuk Lun Lee
- Department of Obstetrics and Gynecology, University of Hong Kong, Queen Mary Hospital
- Philip C. N. Chiu
- Department of Obstetrics and Gynecology, University of Hong Kong, Queen Mary Hospital
- Leo Tsz On Lee
- Centre of Reproduction Development and Aging, Faculty of Health Sciences, University of Macau
- Hung-Cheng Lai
- Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University
- Jin-Zhang Zeng
- State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University
- Ho Cheung Shum
- Department of Mechanical Engineering, University of Hong Kong
- Alice S. T. Wong
- School of Biological Sciences, University of Hong Kong
- DOI
- https://doi.org/10.1038/s41467-019-10334-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Tumor cell in the peritoneum are often exposed to shear forces generated by ascitic flow during metastasis. Here, the authors show that metastatic cancer stem cells tether more and roll slower than the non-metastatic counterparts, and that sialyl-Lewisx -P-selectin axis mediates peritoneal metastasis.
