Annals of Hepatology (Nov 2023)

Consensus document on acute-on-chronic liver failure (ACLF) established by the Mexican Association of Hepatology

  • Aldo Torre,
  • Laura Esthela Cisneros-Garza,
  • Mauricio Castillo-Barradas,
  • Nalu Navarro-Alvarez,
  • Ricardo Sandoval-Salas,
  • María Sarai González-Huezo,
  • José Luís Pérez-Hernández,
  • Osvely Méndez-Guerrero,
  • Jesús Alejandro Ruiz-Manríquez,
  • Rafael Trejo-Estrada,
  • Norberto C. Chavez-Tapia,
  • Luis Carlos Solís-Gasca,
  • Carlos Moctezuma-Velázquez,
  • Jonathan Aguirre-Valádez,
  • Judith Flores-Calderón,
  • Fatima Higuera-de-la-Tijera,
  • Ignacio García-Juárez,
  • Nancy Allin Canedo-Castillo,
  • René Malé-Velázquez,
  • Iaarah Montalvo-Gordon,
  • Mario Vilatobá,
  • Ernesto Márquez-Guillén,
  • Jacqueline Córdova-Gallardo,
  • Nayeli Cointa Flores-García,
  • Godolfino Miranda-Zazueta,
  • Belinda Isela Martínez-Saldívar,
  • Víctor Manuel Páez-Zayas,
  • Linda Elsa Muñoz-Espinosa,
  • Francisco Alfonso Solís-Galindo

Journal volume & issue
Vol. 28, no. 6
p. 101140

Abstract

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Acute-on chronic liver failure (ACLF) has been an intensively debated topic mainly due to the lack of a unified definition and diagnostic criteria. The growing number of publications describing the mechanisms of ACLF development, the progression of the disease, outcomes and treatment has contributed to a better understanding of the disease, however, it has also sparked the debate about this condition. As an attempt to provide medical professionals with a more uniform definition that could be applied to our population, the first Mexican consensus was performed by a panel of experts in the area of hepatology in Mexico. We used the most relevant and impactful publications along with the clinical and research experience of the consensus participants. The consensus was led by 4 coordinators who provided the most relevant bibliography by doing an exhaustive search on the topic. The entire bibliography was made available to the members of the consensus for consultation at any time during the process and six working groups were formed to develop the following sections: 1.- Generalities, definitions, and criteria, 2.- Pathophysiology of cirrhosis, 3.- Genetics in ACLF, 4.- Clinical manifestations, 5.- Liver transplantation in ACLF, 6.- Other treatments.

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