Determinants of neonatal seizure among neonates admitted to neonatal intensive care units in the Awi Zone hospitals, 2023: A multi-center unmatched case control study
Tamiru Alene,
Tilahun Degu Tsega,
Tamene Fetene Terefe,
Nigatu Dessalegn,
Zemenu Addis Alem,
Workineh Tamir,
Abrham Amare Tesfa,
Yefiru Andualem Mitiku,
Zewdu Bishaw Aynalem,
Workineh Necho Melaku,
Getachew Amare,
Biresaw Wassihun Alemu
Affiliations
Tamiru Alene
Department of Pediatrics and Child Health Nursing, College of Medicine and Health Sciences, Injibara University, Injibara, Amhara, Ethiopia; Corresponding author.
Tilahun Degu Tsega
Departmrnt of Public Health, College of Medicine and Health Sciences, Injibara University, Injibara, Amhara, Ethiopia
Tamene Fetene Terefe
Department of Pediatrics and Child Health Nursing, College of Medicine and Health Sciences, Injibara University, Injibara, Amhara, Ethiopia
Nigatu Dessalegn
Department of Pediatrics and Child Health Nursing, College of Medicine and Health Sciences, Injibara University, Injibara, Amhara, Ethiopia
Zemenu Addis Alem
Department of Clinical Nursing, Hossana Health Sciences College, southern Nation nationalities and people of Ethiopia, Ethiopia
Workineh Tamir
Department of Medical Laboratory Science, College of Medicine and Health Sciences, Injibara University, Injibara, Amhara, Ethiopia
Abrham Amare Tesfa
Department of Orthopedic Surgery, College of Medicine and Health Sciences, Injibara University, Injibara, Amhara, Ethiopia
Yefiru Andualem Mitiku
Department of Internal Medicine, Injibara General Hospital, Injibara, Amhara, Ethiopia
Zewdu Bishaw Aynalem
Department of Nursing, College of Medicine and Health Sciences, Injibara University, Injibara, Amhara, Ethiopia
Workineh Necho Melaku
Department of Medicine, MSF Holland, Abdurafi Project, Ethiopia
Getachew Amare
Deparment of Midwifery College of Medicine and Health Sciences, Injibara University, Injibara, Amhara, Ethiopia
Biresaw Wassihun Alemu
Department of Midwifery College of Medicine and Health Sciences, Injibara University, Injibara, Amhara, Ethiopia
Background: Neonatal seizure is a common medical emergency that signals severe insult to the neonatal brain. It is a major risk factor for neonatal morbidity and mortality. It has a wide worldwide variation, ranging from 5 per 1000 live births in the United States of America to 39.5 per 1000 live births in Kenya. To decrease this significant figure, it is better to investigate its causes further. Therefore, this study aimed to assess its determinants since there was no prior evidence about it in the context of study area. Objective: Aim to assess the determinants of neonatal seizures among neonates admitted to neonatal intensive care units in the Awi Zone Hospitals, 2023. Methods: An institution based unmatched case-control study was conducted on 531 admitted eligible neonates from January 1, 2023, to May 30, 2023. A pretested tool was employed to collect data. The collected data were coded, edited, and entered into Epi-data version 3.1 and then exported to SPSS 26. Chi-square and odds ratios were used to assess the relationship between factors associated with the occurrence of neonatal seizure. Model goodness of fit was tested by Hosmer and Lemeshow. Bivariate and multivariate analysis was declared at P 37.5 °C [AOR; 4.82 (95 %, CI: 1.82–12.76)], blood glucose level 37.5 °C, blood glucose level <40 g/dl, neonatal sepsis, and perinatal asphyxia. Therefore, the presence of such factors requires prompt recognition and treatment.
