Nature Communications (Mar 2016)

Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain

  • Hiromu Monai,
  • Masamichi Ohkura,
  • Mika Tanaka,
  • Yuki Oe,
  • Ayumu Konno,
  • Hirokazu Hirai,
  • Katsuhiko Mikoshiba,
  • Shigeyoshi Itohara,
  • Junichi Nakai,
  • Youichi Iwai,
  • Hajime Hirase

DOI
https://doi.org/10.1038/ncomms11100
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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While transcranical direct current stimulation (tDCS) is used in clinical setting, its cellular mechanism of action is unclear. Here, Hajime Hirase and colleagues visualize cellular response in mouse brain to tDCS and show robust astrocyte activation that coincide with plasticity changes.