Nature Communications (Oct 2018)
The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD
- Taylor K. Soderborg,
- Sarah E. Clark,
- Christopher E. Mulligan,
- Rachel C. Janssen,
- Lyndsey Babcock,
- Diana Ir,
- Bridget Young,
- Nancy Krebs,
- Dominick J. Lemas,
- Linda K. Johnson,
- Tiffany Weir,
- Laurel L. Lenz,
- Daniel N. Frank,
- Teri L. Hernandez,
- Kristine A. Kuhn,
- Angelo D’Alessandro,
- Linda A. Barbour,
- Karim C. El Kasmi,
- Jacob E. Friedman
Affiliations
- Taylor K. Soderborg
- Department of Pediatrics, Section of Neonatology, University of Colorado Anschutz Medical Campus
- Sarah E. Clark
- Department of Microbiology and Immunology, University of Colorado Anschutz Medical Campus
- Christopher E. Mulligan
- Department of Pediatrics, Section of Neonatology, University of Colorado Anschutz Medical Campus
- Rachel C. Janssen
- Department of Pediatrics, Section of Neonatology, University of Colorado Anschutz Medical Campus
- Lyndsey Babcock
- Department of Pediatrics, Section of Neonatology, University of Colorado Anschutz Medical Campus
- Diana Ir
- Department of Medicine, Division of Infectious Disease, University of Colorado Anschutz Medical Campus
- Bridget Young
- Department of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus
- Nancy Krebs
- Department of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus
- Dominick J. Lemas
- Department of Pediatrics, Section of Neonatology, University of Colorado Anschutz Medical Campus
- Linda K. Johnson
- Department of Pathology, University of Colorado Anschutz Medical Campus
- Tiffany Weir
- Department of Food Science and Human Nutrition, Colorado State University
- Laurel L. Lenz
- Department of Microbiology and Immunology, University of Colorado Anschutz Medical Campus
- Daniel N. Frank
- Department of Medicine, Division of Infectious Disease, University of Colorado Anschutz Medical Campus
- Teri L. Hernandez
- Department of Medicine, Division of Endocrinology, Metabolism & Diabetes, University of Colorado Anschutz Medical Campus
- Kristine A. Kuhn
- Department of Medicine, Division of Rheumatology, University of Colorado Anschutz Medical Campus
- Angelo D’Alessandro
- Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus
- Linda A. Barbour
- Department of Medicine, Division of Endocrinology, Metabolism & Diabetes, University of Colorado Anschutz Medical Campus
- Karim C. El Kasmi
- Department of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition, University of Colorado Anschutz Medical Campus
- Jacob E. Friedman
- Department of Pediatrics, Section of Neonatology, University of Colorado Anschutz Medical Campus
- DOI
- https://doi.org/10.1038/s41467-018-06929-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Infants born to obese mothers have altered microbiome and increased risk of obesity and NAFLD. Here the authors establish causality by showing that maternal obesity-shaped infant gut microbiome induces macrophage dysfunction, inflammation, and diet-induced metabolic disease in germ-free mice.
