Nature Communications (Feb 2016)
Genome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillation
- Chia-Ti Tsai,
- Chia-Shan Hsieh,
- Sheng-Nan Chang,
- Eric Y. Chuang,
- Kwo-Chang Ueng,
- Chin-Feng Tsai,
- Tsung-Hsien Lin,
- Cho-Kai Wu,
- Jen-Kuang Lee,
- Lian-Yu Lin,
- Yi-Chih Wang,
- Chih-Chieh Yu,
- Ling-Ping Lai,
- Chuen-Den Tseng,
- Juey-Jen Hwang,
- Fu-Tien Chiang,
- Jiunn-Lee Lin
Affiliations
- Chia-Ti Tsai
- Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital
- Chia-Shan Hsieh
- Department of Life Science, Genome and Systems Biology Degree Program, National Taiwan University
- Sheng-Nan Chang
- Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University
- Eric Y. Chuang
- Department of Life Science, Genome and Systems Biology Degree Program, National Taiwan University
- Kwo-Chang Ueng
- School of Medicine, Chung Shan Medical University
- Chin-Feng Tsai
- School of Medicine, Chung Shan Medical University
- Tsung-Hsien Lin
- Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University and Chung-Ho Memorial Hospital
- Cho-Kai Wu
- Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital
- Jen-Kuang Lee
- Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital
- Lian-Yu Lin
- Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital
- Yi-Chih Wang
- Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital
- Chih-Chieh Yu
- Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital
- Ling-Ping Lai
- Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital
- Chuen-Den Tseng
- Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital
- Juey-Jen Hwang
- Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital
- Fu-Tien Chiang
- Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital
- Jiunn-Lee Lin
- Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital
- DOI
- https://doi.org/10.1038/ncomms10190
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 9
Abstract
Tsai et al. here utilize a multi-stage genome-wide association study in Taiwanese population to show a copy number variation in the intron of potassium interacting channel 1 gene (KCNIP1) to be strongly associated with atrial fibrillation. The study also examines the functionality of KCNIP1 in heart electrophysiological function using cultured myocytes and zebrafish.
