Nature Communications (Nov 2019)
The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis
- Jordan P. Lewandowski,
- James C. Lee,
- Taeyoung Hwang,
- Hongjae Sunwoo,
- Jill M. Goldstein,
- Abigail F. Groff,
- Nydia P. Chang,
- William Mallard,
- Adam Williams,
- Jorge Henao-Meija,
- Richard A. Flavell,
- Jeannie T. Lee,
- Chiara Gerhardinger,
- Amy J. Wagers,
- John L. Rinn
Affiliations
- Jordan P. Lewandowski
- Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University
- James C. Lee
- Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University
- Taeyoung Hwang
- Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University
- Hongjae Sunwoo
- Department of Molecular Biology, Massachusetts General Hospital
- Jill M. Goldstein
- Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University
- Abigail F. Groff
- Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University
- Nydia P. Chang
- Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University
- William Mallard
- Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University
- Adam Williams
- The Jackson Laboratory, JAX Genomic Medicine
- Jorge Henao-Meija
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine University of Pennsylvania
- Richard A. Flavell
- Department of Immunobiology and Howard Hughes Medical Institute, Yale University, School of Medicine
- Jeannie T. Lee
- Department of Molecular Biology, Massachusetts General Hospital
- Chiara Gerhardinger
- Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University
- Amy J. Wagers
- Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University
- John L. Rinn
- Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University
- DOI
- https://doi.org/10.1038/s41467-019-12970-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
LncRNA loci potentially contain multiple modes that can exert function, including DNA regulatory elements. Here, the authors generated genetic models in mice to dissect the role of the syntenically conserved lncRNA Firre in the context of hematopoiesis.
