New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus <i>Lecanicillium fusisporum</i>
Xinya Xu,
Yanhui Tan,
Chenghai Gao,
Kai Liu,
Zhenzhou Tang,
Chunju Lu,
Haiyan Li,
Xiaoyong Zhang,
Yonghong Liu
Affiliations
Xinya Xu
Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
Yanhui Tan
State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin 541004, China
Chenghai Gao
Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
Kai Liu
Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
Zhenzhou Tang
Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
Chunju Lu
Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
Haiyan Li
Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
Xiaoyong Zhang
College of Marine Sciences, South China Agricultural University, Guangzhou 510642, China
Yonghong Liu
Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
Seven rare C3-C6 reduced 3-acyl tetramic acid derivatives, lecanicilliumins A–G (1–7), along with the known analogue cladosporiumin D (8), were obtained from the extract of the deep-sea-derived fungus Lecanicillium fusisporum GXIMD00542 within the family Clavipitacae. Their structures were elucidated by extensive spectroscopic data analysis, quantum chemistry calculations and chemical reaction. Compounds 1, 2, 5–7 exhibited moderate anti-inflammatory activity against NF-κB production using lipopolysaccharide (LPS) induced RAW264.7 cells with EC50 values range of 18.49–30.19 μM.
