Natural Bioactive Compounds Targeting Histone Deacetylases in Human Cancers: Recent Updates
Abdelhakim Bouyahya,
Naoufal El Hachlafi,
Tarik Aanniz,
Ilhame Bourais,
Hamza Mechchate,
Taoufiq Benali,
Mohammad Ali Shariati,
Pavel Burkov,
José M. Lorenzo,
Polrat Wilairatana,
Mohammad S. Mubarak,
Nasreddine El Omari
Affiliations
Abdelhakim Bouyahya
Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat 10106, Morocco
Naoufal El Hachlafi
Microbial Biotechnology and Bioactive Molecules Laboratory, Sciences and Technologies Faculty, Sidi Mohmed Ben Abdellah University, Imouzzer Road Fez, Fez B.P. 1796, Morocco
Tarik Aanniz
Medical Biotechnology Laboratory, Rabat Medical & Pharmacy School, Mohammed V University in Rabat, Rabat B.P. 6203, Morocco
Ilhame Bourais
Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat 10106, Morocco
Hamza Mechchate
Laboratory of Biotechnology, Environment, Agri-Food and Health (LBEAS), Faculty of Sciences, Sidi Mohamed Ben Abdellah University, Fez B.P. 1796, Morocco
Taoufiq Benali
Environment and Health Team, Polydisciplinary Faculty of Safi, Cadi Ayyad University, Sidi Bouzid B.P. 4162, Morocco
Mohammad Ali Shariati
Department of Scientific Research, K. G. Razumovsky Moscow State University of Technologies and Management (The First Cossack University), 73 Zemlyanoy Val, 109004 Moscow, Russia
Pavel Burkov
Center for Biotechnology of Animal Reproduction, South Ural State Agrarian University, 13 Gagarin St., 457100 Troitsk, Russia
José M. Lorenzo
Centro Tecnológico de la Carne de Galicia, Rúa Galicia No.4, Parque Tecnológico de Galicia, 32900 San Cibrao das Viñas, Spain
Polrat Wilairatana
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
Mohammad S. Mubarak
Department of Chemistry, The University of Jordan, Amman 11942, Jordan
Nasreddine El Omari
Laboratory of Histology, Embryology, and Cytogenetic, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat 10100, Morocco
Cancer is a complex pathology that causes a large number of deaths worldwide. Several risk factors are involved in tumor transformation, including epigenetic factors. These factors are a set of changes that do not affect the DNA sequence, while modifying the gene’s expression. Histone modification is an essential mark in maintaining cellular memory and, therefore, loss of this mark can lead to tumor transformation. As these epigenetic changes are reversible, the use of molecules that can restore the functions of the enzymes responsible for the changes is therapeutically necessary. Natural molecules, mainly those isolated from medicinal plants, have demonstrated significant inhibitory properties against enzymes related to histone modifications, particularly histone deacetylases (HDACs). Flavonoids, terpenoids, phenolic acids, and alkaloids exert significant inhibitory effects against HDAC and exhibit promising epi-drug properties. This suggests that epi-drugs against HDAC could prevent and treat various human cancers. Accordingly, the present study aimed to evaluate the pharmacodynamic action of different natural compounds extracted from medicinal plants against the enzymatic activity of HDAC.
