Continuous biomarker monitoring with single molecule resolution by measuring free particle motion

Alissa D. Buskermolen; Yu-Ting Lin; Laura van Smeden; Rik B. van Haaften; Junhong Yan; Khulan Sergelen; Arthur M. de Jong; Menno W. J. Prins

doi:10.1038/s41467-022-33487-3

Nature Communications (Oct 2022)

Continuous biomarker monitoring with single molecule resolution by measuring free particle motion

Alissa D. Buskermolen,
Yu-Ting Lin,
Laura van Smeden,
Rik B. van Haaften,
Junhong Yan,
Khulan Sergelen,
Arthur M. de Jong,
Menno W. J. Prins

Affiliations

Alissa D. Buskermolen: Department of Biomedical Engineering, Eindhoven University of Technology
Yu-Ting Lin: Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology
Laura van Smeden: Department of Biomedical Engineering, Eindhoven University of Technology
Rik B. van Haaften: Department of Applied Physics, Eindhoven University of Technology
Junhong Yan: Helia Biomonitoring
Khulan Sergelen: Department of Biomedical Engineering, Eindhoven University of Technology
Arthur M. de Jong: Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology
Menno W. J. Prins: Department of Biomedical Engineering, Eindhoven University of Technology

DOI: https://doi.org/10.1038/s41467-022-33487-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Various applications would benefit from the ability to continuously measure biomolecules. Here the authors describe a biosensing technology based on the free diffusion of biofunctionalized particles hovering over a sensor surface, which enables monitoring of analytes (pM-µM) over long timespans.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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