Nature Communications (Aug 2018)

CFP1 coordinates histone H3 lysine-4 trimethylation and meiotic cell cycle progression in mouse oocytes

  • Qian-Qian Sha,
  • Xing-Xing Dai,
  • Jun-Chao Jiang,
  • Chao Yu,
  • Yu Jiang,
  • Junping Liu,
  • Xiang-Hong Ou,
  • Song-Ying Zhang,
  • Heng-Yu Fan

DOI
https://doi.org/10.1038/s41467-018-05930-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 17

Abstract

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The transcription-independent function of trimethylation of histone H3 (H3K4me) in cell division is unclear. Here, Heng-Yu Fan and colleagues report that CFP1, a subunit of the H3K4 methyltransferase, is required for oocyte meiosis, being phosphorylated and degraded during cell cycle transition.