INDICATORS OF THE FUNCTIONING OF THE ANTIOXIDANT SYSTEM OF BLOOD AND ORAL FLUID IN WOMEN SUFFERING FROM PELVIC INFLAMMATORY DISEASES

Abstract

Aim. Evaluation of the features of functioning of the antioxidant system of blood and oral fluid in women suffering from chronic endometritis complicated by the bilateral salpingo-oophoritis. Materials and methods. 85 women participated in the study. The first group consisted of 30 practically healthy women. The second group included 29 patients with chronic endometritis in the exacerbation phase, the third group was represented by patients with a combined course of chronic endometritis and bilateral salpingo-oophoritis in the exacerbation phase (n=26). In the erythrocyte suspension and oral fluid, the activity of catalase and superoxide dismutase, glutathione peroxidase and glutathione reductase was assessed; in addition, the concentration of reduced glutathione was assessed in erythrocytes. Results. The obtained data reflect the development of an imbalance in the antioxidant system of blood and oral fluid that develops in patients with inflammatory diseases of the pelvic organs. Changes in the blood and oral fluid did not coincide completely, which was expressed by the relative insufficiency of superoxide dismutase activity in the blood (the ratio of activity of catalase and superoxide dismutase 1.3-1.8) and catalase in the oral fluid (the ratio of the activity of catalase and superoxide dismutase 0.5-0.8). It is also interesting to note that the studied indicators after the therapeutic measures characterized still more significant depletion of the antioxidant system, and for the most part it was characteristic of the oral fluid (the ratio of the activity of catalase and superoxide dismutase 0.05-0.1). This may be due to the intensive involvement of antioxidants in the recovery of the body. Conclusion. The results of the study suggest the prospect of additional metabolic correction of the antioxidant orientation to the standard therapy used for the treatment of pelvic inflammatory diseases. The pronounced changes in the biochemical parameters of the oral fluid make it possible to judge the possibility of using it for noninvasive laboratory evaluation of metabolic disorders in women with chronic endometritis and salpingo-oophoritis.

Keywords

• chronic endometritis
• salpingo-oophoritis
• antioxidant defense
• oxidative stress