Journal of Lipid Research (Mar 2009)
Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population[S]
- E. Shyong Tai,
- Xue Ling Sim,
- Twee Hee Ong,
- Tien Yin Wong,
- Seang Mei Saw,
- Tin Aung,
- Sekar Kathiresan,
- Marju Orho-Melander,
- Jose M. Ordovas,
- Jonathan T. Tan,
- Mark Seielstad
Affiliations
- E. Shyong Tai
- Department of Endocrinology, Singapore General Hospital, Singapore, National University of Singapore, Singapore; Center for Molecular Epidemiology, National University of Singapore, Singapore; Singapore Eye Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Community Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Genome Institute of Singapore, Singapore; Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia; Cardiology Division, Massachusetts General Hospital, Boston, MA; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Sweden; Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA
- Xue Ling Sim
- Department of Endocrinology, Singapore General Hospital, Singapore, National University of Singapore, Singapore; Center for Molecular Epidemiology, National University of Singapore, Singapore; Singapore Eye Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Community Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Genome Institute of Singapore, Singapore; Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia; Cardiology Division, Massachusetts General Hospital, Boston, MA; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Sweden; Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA
- Twee Hee Ong
- Department of Endocrinology, Singapore General Hospital, Singapore, National University of Singapore, Singapore; Center for Molecular Epidemiology, National University of Singapore, Singapore; Singapore Eye Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Community Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Genome Institute of Singapore, Singapore; Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia; Cardiology Division, Massachusetts General Hospital, Boston, MA; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Sweden; Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA
- Tien Yin Wong
- Department of Endocrinology, Singapore General Hospital, Singapore, National University of Singapore, Singapore; Center for Molecular Epidemiology, National University of Singapore, Singapore; Singapore Eye Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Community Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Genome Institute of Singapore, Singapore; Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia; Cardiology Division, Massachusetts General Hospital, Boston, MA; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Sweden; Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA
- Seang Mei Saw
- Department of Endocrinology, Singapore General Hospital, Singapore, National University of Singapore, Singapore; Center for Molecular Epidemiology, National University of Singapore, Singapore; Singapore Eye Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Community Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Genome Institute of Singapore, Singapore; Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia; Cardiology Division, Massachusetts General Hospital, Boston, MA; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Sweden; Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA
- Tin Aung
- Department of Endocrinology, Singapore General Hospital, Singapore, National University of Singapore, Singapore; Center for Molecular Epidemiology, National University of Singapore, Singapore; Singapore Eye Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Community Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Genome Institute of Singapore, Singapore; Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia; Cardiology Division, Massachusetts General Hospital, Boston, MA; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Sweden; Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA
- Sekar Kathiresan
- Department of Endocrinology, Singapore General Hospital, Singapore, National University of Singapore, Singapore; Center for Molecular Epidemiology, National University of Singapore, Singapore; Singapore Eye Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Community Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Genome Institute of Singapore, Singapore; Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia; Cardiology Division, Massachusetts General Hospital, Boston, MA; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Sweden; Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA
- Marju Orho-Melander
- Department of Endocrinology, Singapore General Hospital, Singapore, National University of Singapore, Singapore; Center for Molecular Epidemiology, National University of Singapore, Singapore; Singapore Eye Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Community Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Genome Institute of Singapore, Singapore; Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia; Cardiology Division, Massachusetts General Hospital, Boston, MA; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Sweden; Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA
- Jose M. Ordovas
- Department of Endocrinology, Singapore General Hospital, Singapore, National University of Singapore, Singapore; Center for Molecular Epidemiology, National University of Singapore, Singapore; Singapore Eye Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Community Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Genome Institute of Singapore, Singapore; Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia; Cardiology Division, Massachusetts General Hospital, Boston, MA; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Sweden; Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA
- Jonathan T. Tan
- Department of Endocrinology, Singapore General Hospital, Singapore, National University of Singapore, Singapore; Center for Molecular Epidemiology, National University of Singapore, Singapore; Singapore Eye Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Community Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Genome Institute of Singapore, Singapore; Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia; Cardiology Division, Massachusetts General Hospital, Boston, MA; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Sweden; Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA
- Mark Seielstad
- Department of Endocrinology, Singapore General Hospital, Singapore, National University of Singapore, Singapore; Center for Molecular Epidemiology, National University of Singapore, Singapore; Singapore Eye Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Community Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Genome Institute of Singapore, Singapore; Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia; Cardiology Division, Massachusetts General Hospital, Boston, MA; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Sweden; Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA
- Journal volume & issue
-
Vol. 50,
no. 3
pp. 514 – 520
Abstract
We conducted a cross-sectional study of Malay participants aged 40–80 years (n = 2,932) to examine the associations between polymorphisms at newly identified, lipid-associated loci with blood lipid levels and prevalent cardiovascular disease (CVD) in a Malay population in Asia. A polymorphism adjacent to the TRIB1 locus (rs17321515) was associated with elevated total cholesterol and LDL-cholesterol (LDL-C) after adjustment for age and sex (both P values <0.007) and with increased risk of coronary heart disease and CVD [odds ratio (OR) 1.23, 95% confidence interval (95% CI) 1.03–1.46; and OR 1.2, 95% CI 1.02–1.42, respectively] under an additive model of inheritance. In addition, using recessive models of inheritance, polymorphisms on chromosome 19 adjacent to the CILP2 and PBX4 loci (rs16996148) and on chromosome 1 at the GALNT2 locus (rs4846914) were associated with elevated HDL-C (P = 0.005) and lower LDL-C (P = 0.048), respectively. Although novel, the former is consistent with the association between this polymorphism and lower blood triglycerides observed in the initial studies conducted in populations of European ancestry. Neither showed statistically significant association with CVD. These observations should form the basis of further investigation to identify the causative polymorphisms at this locus, and also to understand the mechanistic roles that this protein may play in lipoprotein metabolism in Asians and other populations.
