Nature Communications (Sep 2020)
DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice
- Xiaozhou Li,
- Jian Pan,
- Huiling Li,
- Guangdi Li,
- Xiangfeng Liu,
- Bohao Liu,
- Zhibiao He,
- Zhengyu Peng,
- Hongliang Zhang,
- Yijian Li,
- Xudong Xiang,
- Xiangping Chai,
- Yunchang Yuan,
- Peilin Zheng,
- Feng Liu,
- Dongshan Zhang
Affiliations
- Xiaozhou Li
- Department of Emergency Medicine, The Second Xiangya Hospital, Central South University
- Jian Pan
- Department of Emergency Medicine, The Second Xiangya Hospital, Central South University
- Huiling Li
- Department of Ophthalmology, The Second Xiangya Hospital, Central South University
- Guangdi Li
- Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University
- Xiangfeng Liu
- Department of Trauma center, The Second Xiangya Hospital, Central South University
- Bohao Liu
- Department of Emergency Medicine, The Second Xiangya Hospital, Central South University
- Zhibiao He
- Department of Emergency Medicine, The Second Xiangya Hospital, Central South University
- Zhengyu Peng
- Department of Emergency Medicine, The Second Xiangya Hospital, Central South University
- Hongliang Zhang
- Department of Emergency Medicine, The Second Xiangya Hospital, Central South University
- Yijian Li
- Department of Urinary Surgery, The Second Xiangya Hospital, Central South University
- Xudong Xiang
- Department of Emergency Medicine, The Second Xiangya Hospital, Central South University
- Xiangping Chai
- Department of Emergency Medicine, The Second Xiangya Hospital, Central South University
- Yunchang Yuan
- Department of Chest Surgery, The Second Xiangya Hospital, Central South University
- Peilin Zheng
- Department of Endocrinology, Shenzhen People’s Hospital, The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology
- Feng Liu
- Department of Metabolism and Endocrinology, Metabolic Syndrome Research Center, Central South University
- Dongshan Zhang
- Department of Emergency Medicine, The Second Xiangya Hospital, Central South University
- DOI
- https://doi.org/10.1038/s41467-020-18304-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
DsbA-L upregulation prevents lipid-induced renal injury in diabetic nephropathy. Here, the authors show that DsbA-L knockout attenuates tubulointerstitial fibrosis in mice, and show that this occurs via activation of Smad3 and p53, which result in modulation of CTGF, a regulator of kidney fibrosis.
