Synthesis and characterization of 5% Ni-ZnO as robust nanocatalyst for Eco-Friendly synthesis of pyrimidines

Abstract

The present disclosure includes synthesis of high 5 % Ni-ZnO nanomaterial and its application as yielding protocol for the synthesis of wide range of pyrimidines using 5 % Ni-ZnO as robust nanocatalyst. The 5 % Ni-ZnO nanomaterial was synthesized by co-precipitation method and it was characterized by powder X-ray Powder Diffraction (XRD), scanning electron microscopy (SEM), Energy Dispersive X-ray (EDS) and High Resolution Transmission Electron Microscopy (HR-TEM) methods. XRD method revealed hexagonal wurtzite crystal lattice with crystallite size of 23.45 nm. SEM indicated high porosity of the synthesized nanomaterial while EDS confirmed the element composition. HR-TEM revealed hexagonal crystals. The synthesized 5 % Ni-ZnO nanomaterial was efficiently utilized for one pot multicomponent synthesis of pyrimidine analogues. The synthesized pyrimidines were structurally confirmed on the basis of NMR analysis. Catalyst dose was optimized and the efficacy of catalyst was tested for various aldehydes, 1,3-carbonyl compounds, urea and thiourea which highlights the generality of the green protocol with ample substrate scope. High yield, short reaction time, simple isolation, and purity of the product with column chromatography are key benefits of the synthetic strategy.

Keywords

• 5% Ni-ZnO
• Co-precipitation
• Pyrimidines
• Green chemistry