A signal motif retains Arabidopsis ER-α-mannosidase I in the cis-Golgi and prevents enhanced glycoprotein ERAD

Jennifer Schoberer; Julia König; Christiane Veit; Ulrike Vavra; Eva Liebminger; Stanley W. Botchway; Friedrich Altmann; Verena Kriechbaumer; Chris Hawes; Richard Strasser

doi:10.1038/s41467-019-11686-9

Nature Communications (Aug 2019)

A signal motif retains Arabidopsis ER-α-mannosidase I in the cis-Golgi and prevents enhanced glycoprotein ERAD

Jennifer Schoberer,
Julia König,
Christiane Veit,
Ulrike Vavra,
Eva Liebminger,
Stanley W. Botchway,
Friedrich Altmann,
Verena Kriechbaumer,
Chris Hawes,
Richard Strasser

Affiliations

Jennifer Schoberer: Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna
Julia König: Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna
Christiane Veit: Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna
Ulrike Vavra: Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna
Eva Liebminger: Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna
Stanley W. Botchway: Central Laser Facility, Science and Technology Facilities Council (STFC), Rutherford Appleton Laboratory, Research Complex at Harwell
Friedrich Altmann: Department of Chemistry, University of Natural Resources and Life Sciences, Vienna
Verena Kriechbaumer: Department of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Gipsy Lane, Headington
Chris Hawes: Department of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Gipsy Lane, Headington
Richard Strasser: Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna

DOI: https://doi.org/10.1038/s41467-019-11686-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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The Arabidopsis ER-α-mannosidase I MNS3 generates N-glycan structures typical of ER-resident glycoproteins. Here Schoberer et al. identify a novel motif that anchors MNS3 to the cis-Golgi, spatially separating MNS3 from ER-localized mannose trimming associated with the ER-associated degradation pathway.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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