Nature Communications (Jan 2021)
Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition
Abstract
The molecular and cellular mechanisms of cortical disinhibition as a common feature of many psychiatric diseases are not fully understood. The authors identify an interaction between NRG1 and Nav1.1 sodium channel as a mechanism of how NRG1 modulates the excitability of GABAergic interneurons.