Nature Communications (Jan 2021)

Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition

  • Yao-Yi Wang,
  • Bing Zhao,
  • Meng-Meng Wu,
  • Xiao-Li Zheng,
  • Longnian Lin,
  • Dong-Min Yin

DOI
https://doi.org/10.1038/s41467-020-20552-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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The molecular and cellular mechanisms of cortical disinhibition as a common feature of many psychiatric diseases are not fully understood. The authors identify an interaction between NRG1 and Nav1.1 sodium channel as a mechanism of how NRG1 modulates the excitability of GABAergic interneurons.