Nature Communications (Sep 2017)

Decidualisation and placentation defects are a major cause of age-related reproductive decline

  • Laura Woods,
  • Vicente Perez-Garcia,
  • Jens Kieckbusch,
  • Xiaoqiu Wang,
  • Francesco DeMayo,
  • Francesco Colucci,
  • Myriam Hemberger

DOI
https://doi.org/10.1038/s41467-017-00308-x
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

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Advanced maternal age has been associated with lower reproductive success and higher risk of pregnancy complications. Here the authors show that maternal ageing-related embryonic abnormalities in mouse are caused by decidualisation and placentation defects that can be rescued by transferring the embryo from an old to a young uterus.