Nature Communications (Mar 2023)
A rare human variant that disrupts GPR10 signalling causes weight gain in mice
- Fleur Talbot,
- Claire H. Feetham,
- Jacek Mokrosiński,
- Katherine Lawler,
- Julia M. Keogh,
- Elana Henning,
- Edson Mendes de Oliveira,
- Vikram Ayinampudi,
- Sadia Saeed,
- Amélie Bonnefond,
- Mohammed Arslan,
- Giles S. H. Yeo,
- Philippe Froguel,
- David A. Bechtold,
- Antony Adamson,
- Neil Humphreys,
- Inês Barroso,
- Simon M. Luckman,
- I. Sadaf Farooqi
Affiliations
- Fleur Talbot
- University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Claire H. Feetham
- Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health, University of Manchester
- Jacek Mokrosiński
- University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Katherine Lawler
- University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Julia M. Keogh
- University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Elana Henning
- University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Edson Mendes de Oliveira
- University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Vikram Ayinampudi
- University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Sadia Saeed
- Department of Metabolism, Digestion and Reproduction, Imperial College London
- Amélie Bonnefond
- Department of Metabolism, Digestion and Reproduction, Imperial College London
- Mohammed Arslan
- School of Life Sciences, Forman Christian College
- Giles S. H. Yeo
- University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Philippe Froguel
- Department of Metabolism, Digestion and Reproduction, Imperial College London
- David A. Bechtold
- Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health, University of Manchester
- Antony Adamson
- Genome Editing Unit, Faculty of Biology, Medicine and Health, University of Manchester
- Neil Humphreys
- Genome Editing Unit, Faculty of Biology, Medicine and Health, University of Manchester
- Inês Barroso
- University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Simon M. Luckman
- Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health, University of Manchester
- I. Sadaf Farooqi
- University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- DOI
- https://doi.org/10.1038/s41467-023-36966-3
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 10
Abstract
The brain-expressed receptor GPR10 is involved in energy homeostasis in mice. Here the authors identify rare loss of function variants in GPR10 in people with severe obesity and showed that one of these variants causes obesity when modelled in mice, suggesting that future studies could explore GPR10 as a potential target for weight-loss therapy.
