Dysfunction of γδ T cells in pediatric chronic active Epstein-Barr virus infection

Junhong Ai; Haijuan Xiao; Linlin Zhang; Honghao Ma; Dong Wang; Dilara Dilmurat; Ran Wang; Zhengde Xie

doi:10.1186/s13052-024-01783-x

Italian Journal of Pediatrics (Oct 2024)

Dysfunction of γδ T cells in pediatric chronic active Epstein-Barr virus infection

Junhong Ai,
Haijuan Xiao,
Linlin Zhang,
Honghao Ma,
Dong Wang,
Dilara Dilmurat,
Ran Wang,
Zhengde Xie

Affiliations

Junhong Ai: Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health
Haijuan Xiao: Department of Infectious Diseases, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health
Linlin Zhang: Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health
Honghao Ma: Hematology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health
Dong Wang: Hematology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health
Dilara Dilmurat: Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health
Ran Wang: Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health
Zhengde Xie: Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health

DOI: https://doi.org/10.1186/s13052-024-01783-x
Journal volume & issue: Vol. 50, no. 1
pp. 1 – 4

Abstract

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Abstract Chronic active Epstein-Barr virus infection (CAEBV) is a progressive and life-threatening disease characterized by persistent or recurrent EBV activation. It has been reported that, γδ T cells, a type of cytotoxic lymphocyte, play a critical role in restricting EBV. However, the functional status of γδ T cells in pediatric CAEBV patients has not yet been described. In this study, flow cytometry analysis was conducted to explore the cytokine production capacity of γδ T cells in CAEBV patients. A diminished frequency of γδ T cells and decreased expression of cytolytic molecule granzyme B were found in CAEBV patients, suggesting a dysfunction in the immune regulatory function of γδ T cells in this disease.

Published in Italian Journal of Pediatrics

ISSN: 1720-8424 (Print); 1824-7288 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Pediatrics
Website: https://ijponline.biomedcentral.com/

About the journal

Abstract

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