Nature Communications (Oct 2019)
Viral N 6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus
- Miaoge Xue,
- Boxuan Simen Zhao,
- Zijie Zhang,
- Mijia Lu,
- Olivia Harder,
- Phylip Chen,
- Zhike Lu,
- Anzhong Li,
- Yuanmei Ma,
- Yunsheng Xu,
- Xueya Liang,
- Jiyong Zhou,
- Stefan Niewiesk,
- Mark E. Peeples,
- Chuan He,
- Jianrong Li
Affiliations
- Miaoge Xue
- Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University
- Boxuan Simen Zhao
- Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago
- Zijie Zhang
- Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago
- Mijia Lu
- Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University
- Olivia Harder
- Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University
- Phylip Chen
- Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital
- Zhike Lu
- Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago
- Anzhong Li
- Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University
- Yuanmei Ma
- Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University
- Yunsheng Xu
- Institute of Translational Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou
- Xueya Liang
- Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University
- Jiyong Zhou
- College of Animal Sciences, Zhejiang University, Hangzhou
- Stefan Niewiesk
- Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University
- Mark E. Peeples
- Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital
- Chuan He
- Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago
- Jianrong Li
- Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University
- DOI
- https://doi.org/10.1038/s41467-019-12504-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 18
Abstract
Here, Xue et al. identify N 6-methyladenosine (m6A) modification sites in RNAs of respiratory syncytial virus (RSV) and show that these sites, particularly sites in the transcript encoding for the viral glycoprotein, affect virus replication in primary human cells and cotton rats.
