Nature Communications (Apr 2020)
Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice
- Julia Duerr,
- Dominik H. W. Leitz,
- Magdalena Szczygiel,
- Dmytro Dvornikov,
- Simon G. Fraumann,
- Clemens Kreutz,
- Piotr K. Zadora,
- Ayça Seyhan Agircan,
- Philip Konietzke,
- Theresa A. Engelmann,
- Jan Hegermann,
- Surafel Mulugeta,
- Hiroshi Kawabe,
- Lars Knudsen,
- Matthias Ochs,
- Daniela Rotin,
- Thomas Muley,
- Michael Kreuter,
- Felix J. F. Herth,
- Mark O. Wielpütz,
- Michael F. Beers,
- Ursula Klingmüller,
- Marcus A. Mall
Affiliations
- Julia Duerr
- Department of Translational Pulmonology, University of Heidelberg, Im Neuenheimer Feld 156
- Dominik H. W. Leitz
- Department of Translational Pulmonology, University of Heidelberg, Im Neuenheimer Feld 156
- Magdalena Szczygiel
- Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Im Neuenheimer Feld 156
- Dmytro Dvornikov
- Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Im Neuenheimer Feld 156
- Simon G. Fraumann
- Department of Translational Pulmonology, University of Heidelberg, Im Neuenheimer Feld 156
- Clemens Kreutz
- Institute of Medical Biometry and Statistics, University of Freiburg, Stefan-Meier-Straße 26
- Piotr K. Zadora
- Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Im Neuenheimer Feld 156
- Ayça Seyhan Agircan
- Department of Translational Pulmonology, University of Heidelberg, Im Neuenheimer Feld 156
- Philip Konietzke
- Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Im Neuenheimer Feld 156
- Theresa A. Engelmann
- Institute of Functional and Applied Anatomy, Hannover Medical School
- Jan Hegermann
- Institute of Functional and Applied Anatomy, Hannover Medical School
- Surafel Mulugeta
- Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard
- Hiroshi Kawabe
- Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine
- Lars Knudsen
- Institute of Functional and Applied Anatomy, Hannover Medical School
- Matthias Ochs
- Institute of Functional and Applied Anatomy, Hannover Medical School
- Daniela Rotin
- Hospital for Sick Children and University of Toronto, 555 University Avenue
- Thomas Muley
- Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Im Neuenheimer Feld 156
- Michael Kreuter
- Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Im Neuenheimer Feld 156
- Felix J. F. Herth
- Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Im Neuenheimer Feld 156
- Mark O. Wielpütz
- Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Im Neuenheimer Feld 156
- Michael F. Beers
- Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard
- Ursula Klingmüller
- Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Im Neuenheimer Feld 156
- Marcus A. Mall
- Department of Translational Pulmonology, University of Heidelberg, Im Neuenheimer Feld 156
- DOI
- https://doi.org/10.1038/s41467-020-15743-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Idiopathic pulmonary fibrosis (IPF) is a devastating disease with poor prognosis. Here, the authors show that deficiency of the E3 ubiqutin-protein ligase Nedd4-2 in airway epithelial cells causes IPF-like disease in adult mice. This model may aid studies of the pathogenesis and therapy of IPF.
