Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway

Yosuke M. Morizawa; Yuri Hirayama; Nobuhiko Ohno; Shinsuke Shibata; Eiji Shigetomi; Yang Sui; Junichi Nabekura; Koichi Sato; Fumikazu Okajima; Hirohide Takebayashi; Hideyuki Okano; Schuichi Koizumi

doi:10.1038/s41467-017-00037-1

Nature Communications (Jun 2017)

Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway

Yosuke M. Morizawa,
Yuri Hirayama,
Nobuhiko Ohno,
Shinsuke Shibata,
Eiji Shigetomi,
Yang Sui,
Junichi Nabekura,
Koichi Sato,
Fumikazu Okajima,
Hirohide Takebayashi,
Hideyuki Okano,
Schuichi Koizumi

Affiliations

Yosuke M. Morizawa: Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi
Yuri Hirayama: Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi
Nobuhiko Ohno: Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences
Shinsuke Shibata: Department of Physiology and Electron Microscope Laboratory, Keio University School of Medicine
Eiji Shigetomi: Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi
Yang Sui: Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences
Junichi Nabekura: Division of Homeostatic Development, National Institute for Physiological Sciences
Koichi Sato: Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University
Fumikazu Okajima: Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University
Hirohide Takebayashi: Division of Neurobiology and Anatomy, Graduate School of Medical and Dental Sciences, Niigata University
Hideyuki Okano: Department of Physiology and Electron Microscope Laboratory, Keio University School of Medicine
Schuichi Koizumi: Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi

DOI: https://doi.org/10.1038/s41467-017-00037-1
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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Astrocytic phagocytosis has been shown to play a role in synaptic pruning during development, but whether adult astrocytes possess phagocytic ability is unclear. Here the authors show that following brain ischemia, reactive astrocytes become phagocytic and engulf debris via the ABCA1 pathway.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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