Antimicrobial Resistance Patterns Amid Community-Acquired Uropathogens in Outpatient Settings of a Tertiary Care Hospital in Thailand

Abstract

Objective: To document the distribution of antimicrobial resistance patterns of community-acquired uropathogens. Materials and Methods: Outpatient microbiology data of urine culture results in Songklanagarind Hospital between January to December 2019 were reviewed. Results: This study included 649 episodes of positive urine cultures in 598 patients, in which 80.7% were symptomatic cases. The elderly (median 63 ± IQR 26 years) showed high prevalence of urinary tract infections in this study, for which nearly 80% of all samples were female. The three most common uropathogens identified were: Escherichia coli (E. coli) (69.6%), Klebsiella pneumoniae (9.5%) and Staphylococcus saprophyticus (4.9%). E. coli were highly resistant to ciprofloxacin (49.0 %), cotrimoxazole (41.2%) and ceftriaxone (20.6%), but had a low level of resistance to fosfomycin (0%), and amikacin (0.4%). Conclusion: The antimicrobial resistance pattern of E. coli was high for commonly antimicrobial agents used in outpatients; especially quinolone, cotrimoxazole and cephalosporin. However, due to low resistance levels, fosfomycin and amikacin could be considered as effective treatment options for community acquired UTIs in our study.

Keywords

• community
• urinary tract infection
• antibiotic resistance