Molecules (Sep 2020)

UCNP-based Photoluminescent Nanomedicines for Targeted Imaging and Theranostics of Cancer

  • Evgenii L. Guryev,
  • Anita S. Smyshlyaeva,
  • Natalia Y. Shilyagina,
  • Evgeniya A. Sokolova,
  • Samah Shanwar,
  • Alexey B. Kostyuk,
  • Alexander V. Lyubeshkin,
  • Alexey A. Schulga,
  • Elena V. Konovalova,
  • Quan Lin,
  • Indrajit Roy,
  • Irina V. Balalaeva,
  • Sergey M. Deyev,
  • Andrei V. Zvyagin

DOI
https://doi.org/10.3390/molecules25184302
Journal volume & issue
Vol. 25, no. 18
p. 4302

Abstract

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Theranostic approach is currently among the fastest growing trends in cancer treatment. It implies the creation of multifunctional agents for simultaneous precise diagnosis and targeted impact on tumor cells. A new type of theranostic complexes was created based on NaYF4: Yb,Tm upconversion nanoparticles coated with polyethylene glycol and functionalized with the HER2-specific recombinant targeted toxin DARPin-LoPE. The obtained agents bind to HER2-overexpressing human breast adenocarcinoma cells and demonstrate selective cytotoxicity against this type of cancer cells. Using fluorescent human breast adenocarcinoma xenograft models, the possibility of intravital visualization of the UCNP-based complexes biodistribution and accumulation in tumor was demonstrated.

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