Nature Communications (Mar 2023)

Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration

  • Phong Quoc Nguyen,
  • Sonia Huecas,
  • Amna Asif-Laidin,
  • Adrián Plaza-Pegueroles,
  • Beatrice Capuzzi,
  • Noé Palmic,
  • Christine Conesa,
  • Joël Acker,
  • Juan Reguera,
  • Pascale Lesage,
  • Carlos Fernández-Tornero

DOI
https://doi.org/10.1038/s41467-023-37109-4
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 13

Abstract

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Cryo-EM structures of Ty1 integrase-Pol III complexes reveal determinants of Ty1 targeting upstream of Pol III-transcribed genes, and a functional impact of the integrase on Pol III activity that may increase the probability of Ty1 integration.